Liquid-liquid electrochemistry

The electrochemical behaviour at interfaces formed between immiscible liquid phases was first investigated at the beginning of the 20th century by Nernst and Riesenfeld. Although the behaviour of electrified oil-water interfaces has been the subject of much research, its use as the basis for bioanalytical detection purposes has not been fully addressed. The goal of the Life Sciences Interface Group in this area of endeavour is to establish methods and protocols that will enable the direct, label-free detection of biomarkers in biological samples. To this end, we investigate voltammetric behaviour of biological molecules such as proteins, peptides and small molecules such as drugs, food additives and neurotransmitters at these interfaces, as well as the development of micro-interfaces (a.k.a. micro-ITIES or µITIES) based on micromachined silicon membranes and nanopore arrays (nano-ITIES).


Further information:

G. Herzog, D.W.M. Arrigan, Electrochemical strategies for the label-free detection of amino acids, peptides and proteins, Analyst, 132 (2007) 615-632. DOI: 10.1039/b701472d.

D.W.M. Arrigan, Bioanalytical detection based on electrochemistry at interfaces between immiscible liquids, Analytical Letters, 41 (2008) 3233-3252. DOI: 10.1080/00032710802518197.



This research was funded by Science Foundation Ireland (02/IN.1/B84 and 07/IN.1/B967) the Irish Research Council for Science, Engineering and Technology (RS/2004/74; RS/2005/122; and PD/2005/23) and the European Commission, Marie Curie Transfer of Knowledge Programme (MTKD-CT-2005-029568), This research was also supported by the Irish Higher Education Authority Programme for Research in Third Level Institutions (PRTLI)

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