Toxicity Monitoring System
Monitoring toxicity with high sensitivity, rapidly, in parallel with a multi-sensing function, at low cost and in the field, is of great interest in the fields of clinical diagnostics, environmental monitoring, food safety and security. This is important because there is a demand for a higher standard of validated in vitro toxicity test assays and technologies based on the need for greater accuracy and reliability from both a regulatory and industrial perspective. Impedance analysis enables accurate, sensitive and reliable assays to be performed in real time and under constant automated monitoring. These types of biosensors offer the potential to study the behavior of mammalian cells in a non-destructive assay format. The Life Sciences Interface Group have developed impedance sensors which are based on inter-digitated electrode (IDE) structures and have been packaged into biochips. These sensors have been used to monitor toxicity of pollutants and hazardous chemicals on cells relevant to human health.